What is RPL?
RPL means Repeat/Recurrant Pregnancy Loss. Generally when a woman has had two or more losses confirmed by an OB, they are sent for RPL testing. Many doctors have varying views on when a woman should receive RPL testing. Some may say after “x” many weeks, three losses, or even after a certain age and a certain number of losses. Only your doctor will have the correct answer for you and your situation. If you ever question your doctors decision, it is best to seek a second, professional, opinion.
What will they test for?
Studies have concluded that about half of all first trimester miscarriages are the result of chromosomal abnormalities. These generally occur on a sporadic basis, meaning that they are random occurrences. They are, however, related to the age of the woman and are more likely to occur with advancing maternal age.
Research suggests that after a couple has had 2 or more unexplained miscarriages, there is a 2-5% risk that one member of the couple is a carrier of a balanced chromosome rearrangement. Chromosomal analysis of the products of conception (the miscarried fetal tissue) and of the woman and her partner may provide additional important information that will affect future reproductive decisions and additional testing recommendations.
There are several hormonal imbalances that can contribute to miscarriage rates. These can be evaluated with simple blood tests and treated if present. The recommended hormonal testing will depend up on the symptoms experienced, but may include thyroid, prolactin, follicle stimulating hormone, fasting glucose and insulin levels.
Hematologic and Immunologic Testing
Several blood disorders have been implicated in recurrent miscarriages. Women with abnormal blood clotting may be predisposed to early or late miscarriage and women with high risk personal or family histories should be tested. Women with these disorders have a high success rate when properly treated. Testing and treatment of low risk patients continues to be debated among physicians, however even in these cases, the most common abnormalities should be ruled out.
Distortion of the uterine cavity may be found in approximately 10% to 15% of women with recurrent pregnancy losses.
There are some great online resources to finding out how much testing will cost, a breakdown of each area of testing and what they all mean. Once you get tested and talk to your doctor, you can then move forward. Never start your own treatment based on what is found online. Only your doctor will know the best way to treat you and help you achieve a healthy pregnancy.
(RPL Overview) http://emedicine.medscape.com/article/260495-overview
(Should you ask for Genetic Testing?) https://www.dnadirect.com/web/article/testing-for-genetic-disorders/recurrent-pregnancy-loss/50/who-should-consider-testing
(Information on testing cost and breakdown) http://www.fertilityplus.org/faq/miscarriage/rpl.html
Check back for information on Infertility information and testing information and some of the common factors into fertility difficulties.
Feel free to add any questions or comments in the comments section below or in this thread on TTCAL- RPL Blog Post- Link and Discussion/Questions